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Since the fifties , fair sex were told all the eggs they ’d ever carry were create before they were hold . A distich years back , however , inquiry on black eye suggested eggs might be generate later in life-time . That give a gleaming of Bob Hope to women who suffered infertility problems . But the promise has obviously been dashed by a new study led by University of South Florida biologists Lin Liu and David Keefe . The dogma that a womanhood ’s eggs - making days are limited was challenged by a team lead by Harvard reproductive endocrinologist Jonathan Tilly who print studies channel on mice in 2004 and 2005 . " The implications of Tilly ’s group ’s workplace may be less exciting forhuman fertilityif the work done by Liu ’s team is confirmed by similar or substitute approaches , " said Emre Seli , a Yale University molecular gamete biologist who was not involved in the inquiry . After Tilly ’s enquiry on female mice farm eggs later in life was published , richness specialist Keefe say women came into his office with a untrue hope about their future fertility , presume that scientists were well on their means to regenerating eggs . Still , MD have notice in IVF ( in vitro fertilization ) clinics that woman do not yield new testicle later on in life . " In Tilly ’s articles , there was a spot of overselling the construct , " enjoin Keefe , a physician scientist . " It was not really fair to the patients . " To define wheneggsare made , Liu and colleagues examine the genes in ovaries of 12 women age 28 to 53 and compared those with genes of distaff fetuses . In the fetus , the researchers pinpoint factor responsible for for egg production , but in the grownup women , the scientist found no grounds of such " oogenesis " cistron . The results were published in the March egress of the journalDevelopmental Biology . In reaction to Liu ’s results , Tilly wrote a response in a unlike diary , Cell Cycle , stating in its April effect , " It is disappointing to see argument against the possibility of postnatal oogenesis in mammalian still being drawn using exclusively an ' absence seizure of evidence ' approach . " Yet ovarian physiologist , including Janice Bahr at the University of Illinois at Urbana - Champaign , mean differently . Bahr , who was not involved in any of the studies , find Liu ’s workplace punctilious and solid . She did , however , agree with Tilly ’s desire to challenge old idea with new engineering science . From the 1850s until 1951 , scientists assumed adult female made new egg during intimate ripening . But research published in 1951 by life scientist Solly Zuckerman changed people ’s thinking when he showed that a female is stand with all of her eggs . " Because of the new technique available to us , it is always good for science to reexamine theory , " Bahr enjoin . " But then when we do examine them , we really need to present tight information to confirm that a long control theory is n’t true . With our new cock , we can ask : Will this hypothesis established in 1950 still stand today ? " she said . " The Liu paper has confirm Zuckerman ’s inquiry . "
David Keefe, MD, (left) and Lin Liu, PhD, of the University of South Florida College of Medicine.
