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The contest among the various families of fungus kingdom that live in hoi polloi ’s mouthpiece may offer a cue to finding new handling for the unwritten transmission called thrush , harmonize to a new study .
Researchers found differences between the prevalence of kingdom Fungi in the mouthpiece of people with HIV and people who are not infected with HIV . Moreover , a good sort of fungus that was more abundant in healthy masses was able to quell the growth of harmful kingdom Fungi that was more mutual inHIV patients .
Treatment of mice with a solution full of Pichia fungi reduces the extent of tissue invasion by Candida (see arrows) in the tongue. This image shows (A) untreated and (B) Pichia spent medium treated mice tissue.
The findings may taper the manner to a new discussion for thrush in all people , not only those with HIV , the researchers say . The medical name for thrush is unwritten moniliasis ; an overgrowth offungi calledCandidacauses the condition .
" We find that there is a difference in the fungi in the mouth if you are an HIV - infect patient versus non - infected multitude , " enjoin study research worker Mahmoud Ghannoum , a professor at Case Western Reserve University in Cleveland . [ Microscopic Worlds Gallery : Fascinating Fungi ]
The researchers found that when a fungus calledPichiawas prevalent , thenCandidawas less prevalent , and vice versa . " And , therefore , we thought they must antagonize each other , " Ghannoum told Live Science .
In plus , the investigator found that thePichiafungi were more prevailing in multitude without HIV , whereasCandidawas more abundant in people with HIV .
In direct contrast to the divergence in fungi populations , the research worker found little departure in the bacteria in people who did not have HIV compare with those who did have the virus .
In an experiment behave on mice that had thrush , the research worker see that a root full ofPichiafungi halted the maturation ofCandida .
The usage of thePichiasolution work in the mice even better than the drug nystatin , which is typically used to do by hoi polloi who have thrush , the researchers say .
" We have the electric potential of acquire a new drug to process this disease [ thrush ] and other fungal infections , " Ghannoum order .
The new discussion could help people who are prone to developing thrush because theirimmune systemhas been compromise — for example , people with diabetes or genus Cancer , Ghannoum read .
" Our next step is to see whetherPichiaitself can be used as a probiotic , or whether compounds that it secretes can be developed into a drug , " he said .
